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Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Identifieur interne : 008316 ( Main/Exploration ); précédent : 008315; suivant : 008317

Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse

Auteurs : C. M. Wade [États-Unis, Australie] ; E. Giulotto [Italie] ; S. Sigurdsson [Suède] ; M. Zoli [Italie] ; S. Gnerre [États-Unis] ; F. Imsland [Suède] ; T. L. Lear [États-Unis] ; D. L. Adelson [Australie] ; E. Bailey [États-Unis] ; R. R. Bellone [États-Unis] ; H. Blöcker [Allemagne] ; O. Distl [Allemagne] ; R. C. Edgar [États-Unis] ; M. Garber [États-Unis] ; T. Leeb [Allemagne, Suisse] ; E. Mauceli [États-Unis] ; J. N. Macleod [États-Unis] ; M. C. T. Penedo [États-Unis] ; J. M. Raison [Australie] ; T. Sharpe [États-Unis] ; J. Vogel [Royaume-Uni] ; L. Andersson [Suède] ; D. F. Antczak [États-Unis] ; T. Biagi [États-Unis] ; M. M. Binns [Royaume-Uni] ; B. P. Chowdhary [Australie] ; S. J. Coleman [États-Unis] ; G. Della Valle [Italie] ; S. Fryc [États-Unis] ; G. Guerin [France] ; T. Hasegawa [Japon] ; E. W. Hall [Irlande (pays)] ; J. Jurka [États-Unis] ; A. Kiialainen [Suède] ; G. Lindgren [Suède] ; J. Liu [États-Unis] ; E. Magnani [Italie] ; J. R. Mickelson ; J. Murray ; S. G. Nergadze [Italie] ; R. Onofrio [États-Unis] ; S. Pedroni [États-Unis] ; M. F. Piras [Italie] ; T. Raudsepp [Australie] ; M. Rocchi ; K. H. R Ed [États-Unis] ; O. A. Ryder ; S. Searle [Royaume-Uni] ; L. Skow [États-Unis] ; J. E. Swinburne ; A. C. Syv Nen [Suède] ; T. Tozaki ; S. J. Valberg ; M. Vaudin ; J. R. White [États-Unis] ; M. C. Zody [États-Unis, Suède] ; E. S. Lander [États-Unis] ; K. Lindblad-Toh [États-Unis]

Source :

RBID : Pascal:09-0480677

Descripteurs français

English descriptors

Abstract

We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.

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Le document en format XML

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<s1>Department of Computer Science. University of Kentucky</s1>
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<title xml:lang="en" level="a">Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse</title>
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<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Center for Human Genetic Research, Massachusetts General Hospital</s1>
<s2>Boston, MA 02114</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Boston, MA 02114</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<inist:fA14 i1="03">
<s1>Faculty of Veterinary Sciences, University of Sydney</s1>
<s2>Sydney, New South Wales 2006</s2>
<s3>AUS</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Giulotto, E" sort="Giulotto, E" uniqKey="Giulotto E" first="E." last="Giulotto">E. Giulotto</name>
<affiliation wicri:level="1">
<inist:fA14 i1="04">
<s1>Diparfimento di Genetica e Microbiologia, Università di Pavia, Via Ferrata 1</s1>
<s2>27100 Pavia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sigurdsson, S" sort="Sigurdsson, S" uniqKey="Sigurdsson S" first="S." last="Sigurdsson">S. Sigurdsson</name>
<affiliation wicri:level="4">
<inist:fA14 i1="05">
<s1>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582</s1>
<s2>75124 Uppsala</s2>
<s3>SWE</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>75124 Uppsala</wicri:noRegion>
<orgName type="university">Université d'Uppsala</orgName>
<placeName>
<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zoli, M" sort="Zoli, M" uniqKey="Zoli M" first="M." last="Zoli">M. Zoli</name>
<affiliation wicri:level="4">
<inist:fA14 i1="06">
<s1>Dipartimento di Biologia, Università di Bologna, Via Selmi 3</s1>
<s2>40126 Bologna</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>40126 Bologna</wicri:noRegion>
<orgName type="university">Université de Bologne</orgName>
<placeName>
<settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Gnerre, S" sort="Gnerre, S" uniqKey="Gnerre S" first="S." last="Gnerre">S. Gnerre</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Imsland, F" sort="Imsland, F" uniqKey="Imsland F" first="F." last="Imsland">F. Imsland</name>
<affiliation wicri:level="4">
<inist:fA14 i1="05">
<s1>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582</s1>
<s2>75124 Uppsala</s2>
<s3>SWE</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>75124 Uppsala</wicri:noRegion>
<orgName type="university">Université d'Uppsala</orgName>
<placeName>
<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lear, T L" sort="Lear, T L" uniqKey="Lear T" first="T. L." last="Lear">T. L. Lear</name>
<affiliation wicri:level="1">
<inist:fA14 i1="07">
<s1>Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky</s1>
<s2>Lexington, KY 40546</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Lexington, KY 40546</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Adelson, D L" sort="Adelson, D L" uniqKey="Adelson D" first="D. L." last="Adelson">D. L. Adelson</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>University of Adelaide, Adelaide</s1>
<s2>South Australia 5005</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>44 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>South Australia 5005</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bailey, E" sort="Bailey, E" uniqKey="Bailey E" first="E." last="Bailey">E. Bailey</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bellone, R R" sort="Bellone, R R" uniqKey="Bellone R" first="R. R." last="Bellone">R. R. Bellone</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>University of Tampa, 401 West Kennedy Boulevard, Box 3F</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Tampa, FL</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Blocker, H" sort="Blocker, H" uniqKey="Blocker H" first="H." last="Blöcker">H. Blöcker</name>
<affiliation wicri:level="1">
<inist:fA14 i1="10">
<s1>Helmholtz Centre for Infection Research</s1>
<s2>Braunschweig</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Braunschweig</wicri:noRegion>
<wicri:noRegion>Helmholtz Centre for Infection Research</wicri:noRegion>
<wicri:noRegion>Helmholtz Centre for Infection Research</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Distl, O" sort="Distl, O" uniqKey="Distl O" first="O." last="Distl">O. Distl</name>
<affiliation wicri:level="3">
<inist:fA14 i1="11">
<s1>Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p</s1>
<s2>30559 Hannover</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Edgar, R C" sort="Edgar, R C" uniqKey="Edgar R" first="R. C." last="Edgar">R. C. Edgar</name>
<affiliation wicri:level="1">
<inist:fA14 i1="12">
<s1>Monterey Drive</s1>
<s2>Tiburon, CA 94920</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Monterey Drive</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Garber, M" sort="Garber, M" uniqKey="Garber M" first="M." last="Garber">M. Garber</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leeb, T" sort="Leeb, T" uniqKey="Leeb T" first="T." last="Leeb">T. Leeb</name>
<affiliation wicri:level="3">
<inist:fA14 i1="11">
<s1>Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p</s1>
<s2>30559 Hannover</s2>
<s3>DEU</s3>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName>
<region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<inist:fA14 i1="13">
<s1>Institute of Genetics, Vetsuisse Faculty, University of Berne, Bremgartenstrasse 109a</s1>
<s2>3001 Berne</s2>
<s3>CHE</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mauceli, E" sort="Mauceli, E" uniqKey="Mauceli E" first="E." last="Mauceli">E. Mauceli</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Macleod, J N" sort="Macleod, J N" uniqKey="Macleod J" first="J. N." last="Macleod">J. N. Macleod</name>
<affiliation wicri:level="1">
<inist:fA14 i1="07">
<s1>Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky</s1>
<s2>Lexington, KY 40546</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Lexington, KY 40546</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Penedo, M C T" sort="Penedo, M C T" uniqKey="Penedo M" first="M. C. T." last="Penedo">M. C. T. Penedo</name>
<affiliation wicri:level="1">
<inist:fA14 i1="14">
<s1>Veterinary Genetics Laboratory, University of California</s1>
<s2>Davis, CA</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Davis, CA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Raison, J M" sort="Raison, J M" uniqKey="Raison J" first="J. M." last="Raison">J. M. Raison</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>University of Adelaide, Adelaide</s1>
<s2>South Australia 5005</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>44 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>South Australia 5005</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Sharpe, T" sort="Sharpe, T" uniqKey="Sharpe T" first="T." last="Sharpe">T. Sharpe</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Vogel, J" sort="Vogel, J" uniqKey="Vogel J" first="J." last="Vogel">J. Vogel</name>
<affiliation wicri:level="1">
<inist:fA14 i1="15">
<s1>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</s1>
<s2>Hinxton, Cambridge, CB10 1SA</s2>
<s3>GBR</s3>
<sZ>21 aut.</sZ>
<sZ>48 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Hinxton, Cambridge, CB10 1SA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Andersson, L" sort="Andersson, L" uniqKey="Andersson L" first="L." last="Andersson">L. Andersson</name>
<affiliation wicri:level="4">
<inist:fA14 i1="05">
<s1>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582</s1>
<s2>75124 Uppsala</s2>
<s3>SWE</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>56 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>75124 Uppsala</wicri:noRegion>
<orgName type="university">Université d'Uppsala</orgName>
<placeName>
<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Antczak, D F" sort="Antczak, D F" uniqKey="Antczak D" first="D. F." last="Antczak">D. F. Antczak</name>
<affiliation wicri:level="4">
<inist:fA14 i1="16">
<s1>Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University</s1>
<s2>Ithaca, NY 14853</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName>
<settlement type="city">Ithaca (New York)</settlement>
<region type="state">État de New York</region>
</placeName>
<orgName type="university">Université Cornell</orgName>
</affiliation>
</author>
<author>
<name sortKey="Biagi, T" sort="Biagi, T" uniqKey="Biagi T" first="T." last="Biagi">T. Biagi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Binns, M M" sort="Binns, M M" uniqKey="Binns M" first="M. M." last="Binns">M. M. Binns</name>
<affiliation wicri:level="1">
<inist:fA14 i1="17">
<s1>Royal Veterinary College, Royal College Street</s1>
<s2>London NW1 0TU</s2>
<s3>GBR</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>London NW1 0TU</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chowdhary, B P" sort="Chowdhary, B P" uniqKey="Chowdhary B" first="B. P." last="Chowdhary">B. P. Chowdhary</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>University of Adelaide, Adelaide</s1>
<s2>South Australia 5005</s2>
<s3>AUS</s3>
<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>44 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>South Australia 5005</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Coleman, S J" sort="Coleman, S J" uniqKey="Coleman S" first="S. J." last="Coleman">S. J. Coleman</name>
<affiliation wicri:level="1">
<inist:fA14 i1="07">
<s1>Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky</s1>
<s2>Lexington, KY 40546</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Lexington, KY 40546</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Valle, G Della" sort="Valle, G Della" uniqKey="Valle G" first="G. Della" last="Valle">G. Della Valle</name>
<affiliation wicri:level="4">
<inist:fA14 i1="06">
<s1>Dipartimento di Biologia, Università di Bologna, Via Selmi 3</s1>
<s2>40126 Bologna</s2>
<s3>ITA</s3>
<sZ>4 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>40126 Bologna</wicri:noRegion>
<orgName type="university">Université de Bologne</orgName>
<placeName>
<settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fryc, S" sort="Fryc, S" uniqKey="Fryc S" first="S." last="Fryc">S. Fryc</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>41 aut.</sZ>
<sZ>55 aut.</sZ>
<sZ>56 aut.</sZ>
<sZ>57 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Guerin, G" sort="Guerin, G" uniqKey="Guerin G" first="G." last="Guerin">G. Guerin</name>
<affiliation wicri:level="1">
<inist:fA14 i1="19">
<s1>INRA, UMR 1313, Génétique Animale et Biologie Intégrative, Biologie Intégrative et Génétique Equine, Bâtiment 440</s1>
<s2>8350, Jouy-en-Josas</s2>
<s3>FRA</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
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</affiliation>
</author>
<author>
<name sortKey="Hasegawa, T" sort="Hasegawa, T" uniqKey="Hasegawa T" first="T." last="Hasegawa">T. Hasegawa</name>
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<inist:fA14 i1="20">
<s1>Equine Research Institute, Japan Racing Association, 321-4 Tokami-cho</s1>
<s2>Utsunomiya, Tochigi 320-0856</s2>
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<sZ>31 aut.</sZ>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Utsunomiya, Tochigi 320-0856</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hall, E W" sort="Hall, E W" uniqKey="Hall E" first="E. W." last="Hall">E. W. Hall</name>
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<inist:fA14 i1="21">
<s1>Animal Genomics Laboratory, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin</s1>
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<sZ>32 aut.</sZ>
</inist:fA14>
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<name sortKey="Jurka, J" sort="Jurka, J" uniqKey="Jurka J" first="J." last="Jurka">J. Jurka</name>
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<s1>Genetic Information Research Institute, 1925 Landings Drive</s1>
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<name sortKey="Kiialainen, A" sort="Kiialainen, A" uniqKey="Kiialainen A" first="A." last="Kiialainen">A. Kiialainen</name>
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<s1>Department of Medical Sciences, Uppsala University</s1>
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<orgName type="university">Université d'Uppsala</orgName>
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<name sortKey="Lindgren, G" sort="Lindgren, G" uniqKey="Lindgren G" first="G." last="Lindgren">G. Lindgren</name>
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<inist:fA14 i1="24">
<s1>Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 597</s1>
<s2>751 24 Uppsala</s2>
<s3>SWE</s3>
<sZ>35 aut.</sZ>
</inist:fA14>
<country>Suède</country>
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<author>
<name sortKey="Liu, J" sort="Liu, J" uniqKey="Liu J" first="J." last="Liu">J. Liu</name>
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<inist:fA14 i1="25">
<s1>Department of Computer Science. University of Kentucky</s1>
<s2>Lexington, KY 40506</s2>
<s3>USA</s3>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Department of Computer Science. University of Kentucky</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Magnani, E" sort="Magnani, E" uniqKey="Magnani E" first="E." last="Magnani">E. Magnani</name>
<affiliation wicri:level="1">
<inist:fA14 i1="04">
<s1>Diparfimento di Genetica e Microbiologia, Università di Pavia, Via Ferrata 1</s1>
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<sZ>2 aut.</sZ>
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<country>Italie</country>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mickelson, J R" sort="Mickelson, J R" uniqKey="Mickelson J" first="J. R." last="Mickelson">J. R. Mickelson</name>
</author>
<author>
<name sortKey="Murray, J" sort="Murray, J" uniqKey="Murray J" first="J." last="Murray">J. Murray</name>
</author>
<author>
<name sortKey="Nergadze, S G" sort="Nergadze, S G" uniqKey="Nergadze S" first="S. G." last="Nergadze">S. G. Nergadze</name>
<affiliation wicri:level="1">
<inist:fA14 i1="04">
<s1>Diparfimento di Genetica e Microbiologia, Università di Pavia, Via Ferrata 1</s1>
<s2>27100 Pavia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>40 aut.</sZ>
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</inist:fA14>
<country>Italie</country>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Onofrio, R" sort="Onofrio, R" uniqKey="Onofrio R" first="R." last="Onofrio">R. Onofrio</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
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</author>
<author>
<name sortKey="Pedroni, S" sort="Pedroni, S" uniqKey="Pedroni S" first="S." last="Pedroni">S. Pedroni</name>
<affiliation wicri:level="1">
<inist:fA14 i1="14">
<s1>Veterinary Genetics Laboratory, University of California</s1>
<s2>Davis, CA</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Davis, CA</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Piras, M F" sort="Piras, M F" uniqKey="Piras M" first="M. F." last="Piras">M. F. Piras</name>
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<inist:fA14 i1="04">
<s1>Diparfimento di Genetica e Microbiologia, Università di Pavia, Via Ferrata 1</s1>
<s2>27100 Pavia</s2>
<s3>ITA</s3>
<sZ>2 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>40 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Raudsepp, T" sort="Raudsepp, T" uniqKey="Raudsepp T" first="T." last="Raudsepp">T. Raudsepp</name>
<affiliation wicri:level="1">
<inist:fA14 i1="08">
<s1>University of Adelaide, Adelaide</s1>
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<sZ>8 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>26 aut.</sZ>
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<country>Australie</country>
<wicri:noRegion>South Australia 5005</wicri:noRegion>
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<author>
<name sortKey="Rocchi, M" sort="Rocchi, M" uniqKey="Rocchi M" first="M." last="Rocchi">M. Rocchi</name>
</author>
<author>
<name sortKey="R Ed, K H" sort="R Ed, K H" uniqKey="R Ed K" first="K. H." last="R Ed">K. H. R Ed</name>
<affiliation wicri:level="1">
<inist:fA14 i1="09">
<s1>University of Tampa, 401 West Kennedy Boulevard, Box 3F</s1>
<s2>Tampa, FL</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
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<country>États-Unis</country>
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<author>
<name sortKey="Ryder, O A" sort="Ryder, O A" uniqKey="Ryder O" first="O. A." last="Ryder">O. A. Ryder</name>
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<author>
<name sortKey="Searle, S" sort="Searle, S" uniqKey="Searle S" first="S." last="Searle">S. Searle</name>
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<inist:fA14 i1="15">
<s1>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</s1>
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<sZ>21 aut.</sZ>
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<country>Royaume-Uni</country>
<wicri:noRegion>Hinxton, Cambridge, CB10 1SA</wicri:noRegion>
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</author>
<author>
<name sortKey="Skow, L" sort="Skow, L" uniqKey="Skow L" first="L." last="Skow">L. Skow</name>
<affiliation wicri:level="1">
<inist:fA14 i1="18">
<s1>College of Veterinary Medidne, Texas A&M University</s1>
<s2>College Station, TX 77843</s2>
<s3>USA</s3>
<sZ>49 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>College Station, TX 77843</wicri:noRegion>
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<author>
<name sortKey="Swinburne, J E" sort="Swinburne, J E" uniqKey="Swinburne J" first="J. E." last="Swinburne">J. E. Swinburne</name>
</author>
<author>
<name sortKey="Syv Nen, A C" sort="Syv Nen, A C" uniqKey="Syv Nen A" first="A. C." last="Syv Nen">A. C. Syv Nen</name>
<affiliation wicri:level="4">
<inist:fA14 i1="23">
<s1>Department of Medical Sciences, Uppsala University</s1>
<s2>75185 Uppsala</s2>
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<sZ>34 aut.</sZ>
<sZ>51 aut.</sZ>
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<country>Suède</country>
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<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
<orgName type="university">Université d'Uppsala</orgName>
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</author>
<author>
<name sortKey="Tozaki, T" sort="Tozaki, T" uniqKey="Tozaki T" first="T." last="Tozaki">T. Tozaki</name>
</author>
<author>
<name sortKey="Valberg, S J" sort="Valberg, S J" uniqKey="Valberg S" first="S. J." last="Valberg">S. J. Valberg</name>
</author>
<author>
<name sortKey="Vaudin, M" sort="Vaudin, M" uniqKey="Vaudin M" first="M." last="Vaudin">M. Vaudin</name>
</author>
<author>
<name sortKey="White, J R" sort="White, J R" uniqKey="White J" first="J. R." last="White">J. R. White</name>
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<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
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<author>
<name sortKey="Zody, M C" sort="Zody, M C" uniqKey="Zody M" first="M. C." last="Zody">M. C. Zody</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
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<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
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<affiliation wicri:level="4">
<inist:fA14 i1="05">
<s1>Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582</s1>
<s2>75124 Uppsala</s2>
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<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
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<country>Suède</country>
<wicri:noRegion>75124 Uppsala</wicri:noRegion>
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<settlement type="city">Uppsala</settlement>
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<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lander, E S" sort="Lander, E S" uniqKey="Lander E" first="E. S." last="Lander">E. S. Lander</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
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<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lindblad Toh, K" sort="Lindblad Toh, K" uniqKey="Lindblad Toh K" first="K." last="Lindblad-Toh">K. Lindblad-Toh</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Broad Institute, 7 Cambridge Center</s1>
<s2>Cambridge, MA 02142</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Cambridge, MA 02142</wicri:noRegion>
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</analytic>
<series>
<title level="j" type="main">Science : (Washington, D.C.)</title>
<title level="j" type="abbreviated">Science : (Wash. D.C.)</title>
<idno type="ISSN">0036-8075</idno>
<imprint>
<date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Science : (Washington, D.C.)</title>
<title level="j" type="abbreviated">Science : (Wash. D.C.)</title>
<idno type="ISSN">0036-8075</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Equus caballus</term>
<term>Genome</term>
<term>Horse</term>
<term>Interspecific comparison</term>
<term>Population genetics</term>
<term>Sequencing</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Séquençage</term>
<term>Génome</term>
<term>Cheval</term>
<term>Génétique population</term>
<term>Comparaison interspécifique</term>
<term>Equus caballus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.</div>
</front>
</TEI>
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<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Italie</li>
<li>Japon</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region>
<li>Basse-Saxe</li>
<li>Canton de Berne</li>
<li>East Middle Sweden</li>
<li>Nouvelle-Galles du Sud</li>
<li>Svealand</li>
<li>Émilie-Romagne</li>
<li>État de New York</li>
</region>
<settlement>
<li>Berne</li>
<li>Bologne</li>
<li>Hanovre</li>
<li>Ithaca (New York)</li>
<li>Sydney</li>
<li>Uppsala</li>
</settlement>
<orgName>
<li>Université Cornell</li>
<li>Université d'Uppsala</li>
<li>Université de Bologne</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree>
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<name sortKey="Mickelson, J R" sort="Mickelson, J R" uniqKey="Mickelson J" first="J. R." last="Mickelson">J. R. Mickelson</name>
<name sortKey="Murray, J" sort="Murray, J" uniqKey="Murray J" first="J." last="Murray">J. Murray</name>
<name sortKey="Rocchi, M" sort="Rocchi, M" uniqKey="Rocchi M" first="M." last="Rocchi">M. Rocchi</name>
<name sortKey="Ryder, O A" sort="Ryder, O A" uniqKey="Ryder O" first="O. A." last="Ryder">O. A. Ryder</name>
<name sortKey="Swinburne, J E" sort="Swinburne, J E" uniqKey="Swinburne J" first="J. E." last="Swinburne">J. E. Swinburne</name>
<name sortKey="Tozaki, T" sort="Tozaki, T" uniqKey="Tozaki T" first="T." last="Tozaki">T. Tozaki</name>
<name sortKey="Valberg, S J" sort="Valberg, S J" uniqKey="Valberg S" first="S. J." last="Valberg">S. J. Valberg</name>
<name sortKey="Vaudin, M" sort="Vaudin, M" uniqKey="Vaudin M" first="M." last="Vaudin">M. Vaudin</name>
</noCountry>
<country name="États-Unis">
<noRegion>
<name sortKey="Wade, C M" sort="Wade, C M" uniqKey="Wade C" first="C. M." last="Wade">C. M. Wade</name>
</noRegion>
<name sortKey="Antczak, D F" sort="Antczak, D F" uniqKey="Antczak D" first="D. F." last="Antczak">D. F. Antczak</name>
<name sortKey="Bailey, E" sort="Bailey, E" uniqKey="Bailey E" first="E." last="Bailey">E. Bailey</name>
<name sortKey="Bellone, R R" sort="Bellone, R R" uniqKey="Bellone R" first="R. R." last="Bellone">R. R. Bellone</name>
<name sortKey="Biagi, T" sort="Biagi, T" uniqKey="Biagi T" first="T." last="Biagi">T. Biagi</name>
<name sortKey="Coleman, S J" sort="Coleman, S J" uniqKey="Coleman S" first="S. J." last="Coleman">S. J. Coleman</name>
<name sortKey="Edgar, R C" sort="Edgar, R C" uniqKey="Edgar R" first="R. C." last="Edgar">R. C. Edgar</name>
<name sortKey="Fryc, S" sort="Fryc, S" uniqKey="Fryc S" first="S." last="Fryc">S. Fryc</name>
<name sortKey="Garber, M" sort="Garber, M" uniqKey="Garber M" first="M." last="Garber">M. Garber</name>
<name sortKey="Gnerre, S" sort="Gnerre, S" uniqKey="Gnerre S" first="S." last="Gnerre">S. Gnerre</name>
<name sortKey="Jurka, J" sort="Jurka, J" uniqKey="Jurka J" first="J." last="Jurka">J. Jurka</name>
<name sortKey="Lander, E S" sort="Lander, E S" uniqKey="Lander E" first="E. S." last="Lander">E. S. Lander</name>
<name sortKey="Lear, T L" sort="Lear, T L" uniqKey="Lear T" first="T. L." last="Lear">T. L. Lear</name>
<name sortKey="Lindblad Toh, K" sort="Lindblad Toh, K" uniqKey="Lindblad Toh K" first="K." last="Lindblad-Toh">K. Lindblad-Toh</name>
<name sortKey="Liu, J" sort="Liu, J" uniqKey="Liu J" first="J." last="Liu">J. Liu</name>
<name sortKey="Macleod, J N" sort="Macleod, J N" uniqKey="Macleod J" first="J. N." last="Macleod">J. N. Macleod</name>
<name sortKey="Mauceli, E" sort="Mauceli, E" uniqKey="Mauceli E" first="E." last="Mauceli">E. Mauceli</name>
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